TerminatedPhase 2/3

Carbon Dioxide Insufflation on Cerebral Microemboli

Stopped: ran out of funding

Canada20 participantsStarted 2008-04

Plain-language summary

The purpose of this study is to determine if blowing carbon dioxide into the surgical field during open-heart surgery to displace retained chest cavity air from the atmosphere will decrease the number of microembolic being introduced into the heart chambers and brain.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * provide informed consent * male or female who are 18 years of age or older * elective patients to undergo mitral valve repair +/- coronary artery bypass surgery * ability to read and write Exclusion Criteria: * patients with a history of stroke, TIA, carotid vascular disease * patients with a contraindication to TEE or MRI * patients with an active history of drug/alcohol dependence or abuse history

What they're measuring

Primary outcome will be the number of emboli as measured by transesophageal echocardiogram and transcranial doppler.

Timeframe: intraoperative

Trial details

NCT IDNCT00715845

SponsorUniversity Health Network, Toronto

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2010-04

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