CompletedNot Applicable

Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm

United States8 participantsStarted 2007-10

Plain-language summary

This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.

Who can participate

Age range12 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Physician diagnosed asthma * Age 12-75 yrs * FEV1 \> 70% predicted * HIB response \> 10 % * No smoking last 6 mo and \< 10 pack yrs * No URI last 4 weeks * No asthma exacerbation last 4 weks * Able to withhold SABA \> 8 hrs and LABA \> 24 hrs Exclusion Criteria: * Other lung disease * Cardiac disease or other condition that would preclude safe participation, on theophylline or leukotriene modifiers

What they're measuring

Change in level of cystLTs and adenosine

Timeframe: Before and after hyperpnea challenge

Trial details

NCT IDNCT00710255

SponsorUniversity of Vermont

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2009-03

View on ClinicalTrials.gov More Asthma, Exercise Induced trials