RATIONALE: Studying tissue samples in the laboratory from participants receiving treatment on the Selenium and Vitamin E Cancer Prevention Trial (SELECT) SWOG-S0000 may help doctors predict a participant's response to treatment and help plan the best treatment. PURPOSE: This phase III trial is studying the effect of vitamin E and/or selenium on colorectal polyps in men enrolled on SELECT Trial SWOG-S0000.
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Effect of Selenium on Colorectal Adenoma (CRA) Occurrence, Analyzed by Active Selenium vs. Selenium Placebo
Timeframe: From 1 year post randomization through study completion
Effect of Selenium on Advanced Neoplasia, Analyzed by Active Selenium vs. Selenium Placebo
Timeframe: From 1 year post randomization through study completion
Effect of Selenium and/or Vitamin E on Colorectal Cancer (CRC) Incidence
Timeframe: From 1 year post randomization through study completion
Effect of Selenium on Occurrences of Multiple (>2) Adenomas
Timeframe: From 1 year post randomization through study completion