Investigation of the Effect of BONISTEIN(R) Bone Blend on Bone Mineral Density/Content and Biomarkers of Bone Health

Inclusion Criteria: * Female * Age 45 (inclusive) to 55 years (inclusive) * Race: Caucasian * Non-smokers / Smokers up to 10 cigarettes/day * Postmenopausal hormone status: 1-3 years since the last spontaneous menstrual bleeding and a follicle-stimulating hormone concentration (FSH) \>75 IU/ml and 17-estradiol (E2) of \< 20 ng/L * Years since menopause between 1-3 years * Natural menopause or total hysterectomy with bilateral salpingo-oophorectomy * Subjects with E2 results within the inclusion criteria range will be assessed on an individual basis if FSH level is less than 75 IU/ml * Assessed as age-related healthy, based on a pre-study examination including medical history, physical examination, ECG, vital signs and clinical laboratory. The examination will be performed by a MD at the study site within 1-2 months prior planned study start for the individual subject. * Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements. * Ability to understand, speak, read and write the English language Exclusion Criteria: * T-score \< -2.5 at total hip and spine (either or both) * Suspect lack of compliance * BMI \> 30 or \< 21 * Use of HRT within the previous 6 months * Use of any drug which might interfere with bone-metabolism (bisphosphate, estrogen receptor modulators, calcitonin) within the previous 12 months * Systematic practice of high intensity exercise * Vegetarian nutritio…