Systemic Bioavailability Study Of Col-118 Administered Topically as a 0.18 % Facial Gel And Brimonidine Ophthalmic Solution 0.2%

Inclusion Criteria: * Male or female ≥18 years of age * Clinical diagnosis of rosacea * A score of ≥ 3 on the CEAS * A score of ≥ 3 on the PSA * IOP ≥ 10 mm Hg * Non-pregnant and non-lactating females Exclusion Criteria: * History of hypersensitivity or allergies to any ingredient of the study drugs, unless approved by the Investigator * Use of brimonidine prescription medications within 14 days prior to Check-in * Use of any over-the-counter (OTC), non-prescription preparations (including vitamins, minerals, and phytotherapeutic/herbal/plant-derived preparations) within 7 days prior to Check-in, unless deemed acceptable by the Investigator * Use of systemic or topical steroids applied to the face 14 days prior to Check in * The use of any Rx or OTC products for the treatment of acne or rosacea within 14 days prior to check in * The use of isotretinoin within 180 days prior to check in