Kidney Damage in Patients Receiving Cisplatin and Ifosfamide for Solid Tumors

DISEASE CHARACTERISTICS: * Diagnosis of a solid tumor * Any location allowed * Metastatic disease allowed * Planned treatment comprising cisplatin and/or ifosfamide as standard chemotherapy PATIENT CHARACTERISTICS: Inclusion criteria: * Life expectancy \> 3 months * Creatinine clearance ≥ 60 mL/min * Must be available for follow up * Not pregnant or nursing * Not under guardianship or in prison Exclusion criteria: * Prior drug-related nephrotoxicity * Acute, uncontrolled urinary infection or \> 48-hours * Pre-existing hemorrhagic cystitis * Weak bladder * Bilateral obstruction of urinary tract * Insufficient, severe bone marrow hypoplasia * Cardiorespiratory condition contraindicating hyperhydration * Hearing impairment * Hypersensitivity to cisplatin or products containing platinum * Major psychiatric condition (severe depression, psychosis, dementia) PRIOR CONCURRENT THERAPY: * No prior yellow fever vaccine, live attenuated vaccine, or phenytoin * No concurrent participation in another biomedical study