CompletedNot Applicable

Insulin and Polycystic Ovary Syndrome

United States21 participantsStarted 2005-11

Plain-language summary

Increased insulin levels leads to increased secretion of D-chiro inositol(DCI) from the kidneys in women with PCOS, but not in normal women. This leads to a reduction in circulating DCI and insulin stimulated release of DCI-IPG.To determine if decreasing circulating insulin directly by inhibition of islet insulin release with diazoxide in obese women with PCOS 1)decreases the renal clearance of DCI and 2) increases the circulating concentration of DCI.

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Obese women with PCOS and normal women aged 18-40, * PCOS less than 8 periods/year, elevated total or free testosterone, normal thyroid function tests and serum prolactin, exclusion of adrenal hyperplasia * Normal regular monthly periods, no clinical evidence of androgen excess, * All Acceptable health on interview, medical history, physical exams and lab tests, signed, witnessed informed consent and ability to comply to study requirements Exclusion Criteria: * DM, clinically significant pulmonary, cardiac, renal, hepatic, neurologic, psychiatric, infectious, neoplastic or malignant disease.

What they're measuring

Renal Clearance of D-chiroinositol (DCI) at 12 Days

Timeframe: 12 days

Level of Circulating D-chiro Inositol (DCI)

Timeframe: 12 days

Trial details

NCT IDNCT00683774

SponsorVirginia Commonwealth University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2008-12

Results submitted2014-05-30

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