Fondaparinux for the Treatment of Heparin-Induced Thrombocytopenia (HIT)

Inclusion Criteria: * high risk for HIT based on "Four Ts score" of 6 or more Exclusion Criteria: * pulmonary emboli at the time of enrollment * arterial thrombosis at the time of enrollment * limb threatening phlegmasia cerulea dolens at the time of enrollment * Calculated Creatinin Clearance less than 50 ml/hr * platelet count less than 50 * Weight less than 50 kg * pregnancy * allergy to fondaparinux * bacterial endocarditis * history of neuraxial anesthesia and post-operative indwelling epidural catheter * active major bleeding (hemodynamically significant or requiring transfusions) * inability to give informed consent