Effect of Lantus and Apidra in Patients With Acute ST Elevation Myocardial Infarction

Inclusion Criteria: * Men or women = or \> 35 years of age presenting to the hospital with hyperglycemia (plasma glucose \>140 mg/dL) and Primary Anterior wall ST-Elevation Myocardial Infarction (AW STEMI) * No history of illicit drug abuse in past year * A minimum of 30 minutes but \< or = 6 hours of continuous pain/symptoms immediately prior to presentation * Subjects who will undergo primary percutaneous coronary intervention (PCI) * At least 2 contiguous precordial leads demonstrating at least 2 mm of ST-segment elevation consistent with anterior wall MI * Signed informed consent and HIPAA documentation (US only) prior to participation in the study * Subjects ability and willingness to adhere to and be compliant with study protocol Exclusion Criteria: * A prior history of Myocardial Infarction (MI) * Subjects who have received any thrombolytic therapy during the current hospital admission * Severe Heart Failure or cardiogenic shock (Killip class 3 or 4) by history or present at the time of screening * Subjects with a plasma glucose \>400 mg/dL or diabetic ketoacidosis (DKA) * History of Type 1 diabetes * Active bleeding * Active malignancy, chronic or other medical conditions likely to result in death over the next one year * Recent hypotension requiring inotropic support in the past 30 days * Participation in another clinical research study in the past 30 days * Pregnant or lactating women (women of childbearing potential must have a negative pregnancy test at study e…