Effectiveness of Lobeline in Treating Symptoms of ADHD in Adult Patients

Inclusion Criteria: * Diagnosis of ADHD, including degree of symptomatology, as determined by a structured clinical assessment based on the DSM-IV (SCID-1); supplemented by administration of the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Epidemiologic version (KSADS-E) and administration of the Conners' Adult ADHD Rating Scale (CAARS); * Healthy males or females aged 21 to 45 years; * A body mass index (BMI) between 18 and 30; * Ability and willingness to provide written consent, comply with study instructions, and commit to all study visits and procedures; * Adequate means of contacting the investigator in case of emergency or have means to be contacted readily by the investigator; * No medical contraindications determined by the following: an adequate medical history, a physical examination including vital signs, 12-lead electrocardiogram (ECG); complete blood count with differential liver function and blood chemistry tests and urinalysis, including urine sample for drug screening; * A negative urine drug test (barbiturates, benzodiazepines, amphetamines, opiates, cocaine, cannabinoids, ethanol) at screening, and at each laboratory day; * Subjects must be non-smokers. A breath sample analysis will be conducted on-site with an Alco-Sensor Intoximeter, and an Innovative Medical Monitoring carbon monoxide (CO) Monitor, and must reveal a CO value of less than or equal to 8 ppm and a negative cotinine urine or saliva test (\>100 ng/mL); * Female…