Dopamine Agonist for Hemispatial Neglect and Motor Deficit Post Stroke (NCT00663338) | Clinical Trial Compass
CompletedPhase 2
Dopamine Agonist for Hemispatial Neglect and Motor Deficit Post Stroke
United Kingdom20 participantsStarted 2010-01
Plain-language summary
The aim of this study is to assess the effect of the drug rotigotine on the syndrome of hemispatial neglect and motor deficits following strokes affecting the right hemisphere of the brain.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Confirmed clinical diagnosis of right-hemisphere stroke.
* Able to give informed consent.
* Presence of left hemispatial neglect defined by a deficit in finding leftward targets on standard cancellation or visual search tests68-70. (A deficit on the line bisection test alone will not be sufficient for inclusion, as a previous study shows that there is no significant relationship between performance on this test and spatial working memory capacity37).
* Presence of motor deficits: all patients will have suffered from first-ever clinically defined stroke resulting in weakness of at least wrist and finger extensors, and hand interossei (to \</= 4+ on the Medical Research Council scale), at the time of recruitment.
* Age over 18 years.
* More than 9 days since stroke-onset (Note that on our protocol patches do not commence until a minimum of 6 days after the study begins. Thus patients will not receive drug / placebo until a minimum of 15 days post-stroke).
* Able and willing to use patches of drug/placebo and assessments at regular intervals as defined by the protocol.
* Able to comply with study requirements.
* If female and of child-bearing potential, subject has a negative serum pregnancy test within two days of enrollment.
Exclusion Criteria:
* Pre-existing neurological conditions that would confound cognitive and motor assessments, e.g. dementia, Parkinson's disease, Multiple Sclerosis.
* Presence of acute concomitant illness, e.g. infection, unstab…
What they're measuring
1
Performance on tests of hemispatial neglect and its cognitive components (spatial working memory and sustained attention).