Aprepitant for PONV Prophylaxis in Outpatient Plastic Surgery

Inclusion Criteria: * Written informed consent * ASA (American Society of Anesthesiologists physical status) 1-3 * Male and female Age 18 to 65 years * Plastic surgical procedure (Breast, Face, Liposuction, etc., and excluding peripheral procedures such as hand surgery and limited-scope split-thickness skin grafts) of at least 1 hour in duration * General anesthesia * Presence of 2 (men)/3 (women) or more risk factors for PONV * Ambulatory surgery with same-day discharge planned Exclusion Criteria: * Patient refusal * Patients who have received other antiemetics prior to their procedure * History of allergy or sensitivity to study drugs * Pregnancy - Patients are asked date of last menstrual period, use of birth control, tubal ligation, if they have had unprotected sexual intercourse and if they think if there is any possibility of being pregnant, and when appropriate, a pregnancy test will be obtained which is the standard of care at Magee-Womens Hospital. * Patients with a history of chronic opioid use (chronic pain syndrome) as these patients will be less likely to have PONV