Rehabilitation Program for Cognitive Deficits in Ugandan Children After Cerebral Malaria (NCT00658450) | Clinical Trial Compass
CompletedNot Applicable
Rehabilitation Program for Cognitive Deficits in Ugandan Children After Cerebral Malaria
Uganda123 participantsStarted 2008-02
Plain-language summary
The purpose of this study is to determine whether computerised cognitive rehabilitation training improves cognition in children who have had cerebral malaria.
Who can participate
Age range5 Years – 15 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
CM group Inclusion Criteria:
* aged five to 15 years, presenting with asexual forms of P. falciparum malaria on a peripheral blood smear, unarousable coma (not able to localize a painful stimulus) and no other cause for coma (normal CSF).
CM group Exclusion Criteria:
* history of or present meningitis, encephalitis, prior CM, sickle cell disease (SCD), HIV infection, epilepsy, multiple seizures, developmental delay and history of hospitalization for malnutrition.
Healthy control group Inclusion Criteria:
* aged five to 15 years with no other illness at present, within two years of the CM child (for CM children aged 5 and 6 years, the HC's age wont go below 5 and for CM children aged 14 and 15, the HC's age wont go above 15 years).
Healthy control group Exclusion Criteria:
* history of or present bacterial meningitis, encephalitis, CM, SCD, HIV infection, history of hospitalization for malnutrition and any chronic illness for which the patient is currently taking medication.