Vaccine Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Inclusion Criteria: * Age \>18 years of age. * World Health Organization (WHO) Grade IV glioma with definitive resection prior to leukapheresis with residual radiographic contrast enhancement on most recent CT or MRI of \<1 cm in maximal diameter in any axial plane. * Karnofsky Performance Status (KPS ) of \> 80% and a Curran Group status of I-IV. Exclusion Criteria: * Radiographic or cytologic evidence of leptomeningeal or multicentric disease at the time of enrollment. * Prior conventional anti-tumor therapy other than steroids, RT, Avastin or TMZ. * Pregnant or need to breast feed during the study period (Negative Beta-Human Chorionic Gonadotrophin \[HCG\] test required). * Requirement for continuous corticosteroids above physiologic levels at time of first vaccination. * Active infection requiring treatment or an unexplained febrile (\> 101.5o F) illness. * Known immunosuppressive disease or human immunodeficiency virus infection. * Patients with unstable or severe intercurrent medical conditions such as severe heart or lung disease. * Allergic or unable to tolerate TMZ for reasons other than lymphopenia. * Patients with previous inguinal lymph node dissection.