Efficacy and Safety of Ceftaroline Versus Linezolid in Subjects With Complicated Skin and Skin Structure Infections

Inclusion Criteria: * Complicated skin and skin structure infection (cSSSI) * Require initial hospitalization, or treatment in an emergency room or urgent care setting Exclusion Criteria: * Hypersensitivity or allergic reaction to any ß-lactam, ceftaroline, linezolid, aztreonam, or to their components * Concomitant use of adrenergic or serotonergic agent * Uncomplicated skin and skin structure infection * Concomitant therapy with any drug known to exhibit a contraindicated drug-drug interaction * More than 24 hours of treatment with an antimicrobial within 96 hours before randomization * Known or suspected endocarditis, osteomyelitis, or septic arthritis * Severely impaired renal function * Evidence of significant hepatic, hematologic, or immunologic disease