CompletedPhase 1/2

Association of Beta-2 Adrenergic Agonist and Corticosteroid Injection in the Treatment of Lipomas

United States10 participantsStarted 2007-10

Plain-language summary

The purpose of this study is to test whether injected medications will increase the amount of fat released by a fat cell. We will compare prednisolone (a synthetic cortisone) combined with isoproterenol (a drug given for asthma) versus using isoproterenol alone. We will also test if injections of isoproterenol and prednisolone will shrink the size of lipomas, which are benign fatty tumors.

Who can participate

Age range

18 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * You are a man or a woman between the ages of 18-60, inclusive. * You have a body mass index (BMI) between 20 and less than 40 kg/m2. BMI is a number calculated from your height and weight. * You have a lipoma (a benign fatty tumor) that is 1 inch or more in diameter under the skin of your abdomen or on another area of your body that is easily accessible to study (such as the thigh). * You have not gained or lost more than 11 pounds in the last 3 months. * Your exercise routine has been stable for the last 3 months or you are sedentary. Sedentary means you do less than 60 minutes of exercise per week. Exclusion Criteria: * You have a history of heart or blood vessel disease. * Your blood pressure is above 140/90 mmHg. * You have type 1 diabetes. * You have a history of kidney or liver disease. * You have thyroid disease that has not been treated. * You are a smoker. * You use a Beta-2 (B2) adrenergic stimulator (a type of drug used to treat asthma), a beta adrenergic blocker (a type of drug used to treat blood pressure) or glucocorticoid medications (a type of drug used to treat immune system disease). * You have a problem with alcoholism or other substance abuse. * You are pregnant or breast feeding.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The Average Percent Volume Reduction in the Lipoma.

Timeframe: Baseline and 4 weeks

Trial details

NCT IDNCT00624416

SponsorPennington Biomedical Research Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2009-03

Results submitted2011-02-10

View on ClinicalTrials.gov More Lipoma trials