UnknownNot Applicable

Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver Resection

Canada50 participantsStarted 2008-02

Plain-language summary

The goal of the study is to determine whether intravenous glucose administration before liver resection preserves hepatic glycogen resulting in improved hepatic metabolic function after the operation. We further investigate whether the benefit of avoiding preoperative fasting is more pronounced in patients undergoing more extensive liver resection.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * American Society of Anesthesiologists class ≤3 * liver resection (one or more liver segments) for primary or secondary malignancy * ability to give informed consent Exclusion Criteria: * signs of severe malnutrition or obesity: body mass index (BMI) \<20 or \>30 kg.m-2, more than 10% involuntary body weight loss over the preceding six months, serum albumin \<35 g.L-1 * chronic viral liver disease * diabetes mellitus * significant cardiorespiratory, renal and neurological disease * musculoskeletal or neuromuscular disease * severe anemia (hemoglobin \<10 g.dL-1) * history of severe sciatica or back surgery or other conditions which contraindicate the use of an epidural catheter

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Rate of albumin synthesis

Timeframe: One day before and one day after surgery

Trial details

NCT IDNCT00623662

SponsorMcGill University Health Centre/Research Institute of the McGill University Health Centre

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-03

Contact for this trial

Ralph Lattermann, MD PhD

514-934-1934 ralph.lattermann@muhc.mcgill.ca

View on ClinicalTrials.gov More Hepatic Insufficiency trials