CompletedNot Applicable

Endothelial Dysfunction and Coronary Artery Spasm

Japan158 participantsStarted 2006-08

Plain-language summary

Non-obstructive coronary artery disease (NOCAD) frequently accounts for myocardial ischemia in women. Endothelial dysfunction is a pathogenic factor in coronary spastic angina (CSA). CSA is an important cause of NOCAD diagnosed invasively by coronary angiography (CAG). Digital reactive hyperemia peripheral arterial tonometry (RH-PAT) provides noninvasive evaluation of endothelial dysfunction. The investigators hypothesized that the fingertip RH-PAT could predict the presence of CSA in women.

Who can participate

Age range40 Years – 90 Years

SexFEMALE

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Inclusion Criteria: * Stable post-menopausal women complaining angina-like chest pain Exclusion Criteria: * Severe valvular disease * Hypertrophic cardiomyopathy * Severe peripheral artery disease * Uncontrolled hypertension * Severe collagen diseases * Acute coronary syndrome

What they're measuring

Ischemic heart disease diagnosed by cardiac catheterization

Timeframe: From Aug 2006 to May 2009

Trial details

NCT IDNCT00619294

SponsorKumamoto University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2009-05

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