TerminatedNot Applicable

Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18:

Stopped: low enrollment low enrollment

United States8 participantsStarted 2002-04

Plain-language summary

Researchers have previously demonstrated loss of heterozygosity in a region on chromosome 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used in this study are specifically described by those authors as showing loss of heterozygosity in 6 of 7 affected families.

Who can participate

SexALL

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Inclusion Criteria: * This is a familial study therefore the only inclusion/exclusion criteria would be that subjects must be a blood relative and over the age of 18. * The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son. Exclusion Criteria: * Not part of the family

What they're measuring

Loss of heterozygosity

Timeframe: January, 2000 through February 2009

Trial details

NCT IDNCT00615628

SponsorState University of New York - Upstate Medical University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2009-12

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