Active — Not RecruitingNot Applicable

Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)

United States10,718 participantsStarted 2007-11

Plain-language summary

Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused by cigarette smoking. The purpose of this study is to evaluate whether certain genetic factors predispose some smokers to develop COPD more than others.

Who can participate

Age range

45 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * At least 10 pack-years of cigarette smoking (although a of nonsmoking controls is also being enrolled) * Self-designation of non-Hispanic white or African-American Exclusion Criteria: * Other lung diseases (except for asthma in participants with COPD) * Pregnant * Cancer (other than skin cancer) in the 5 years prior to study entry * Received antibiotics for a COPD exacerbation in the 1 month prior to study entry * First- or second-degree relative of a previously enrolled study participant

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Forced expiratory volume in 1 second (FEV1)

Timeframe: Measured at baseline

Emphysema, as shown on chest CT scan

Timeframe: Measured at baseline

Airway wall thickness on chest CT scan

Timeframe: Measured at baseline

COPD status (COPD participants versus control group participants)

Timeframe: Measured at baseline

Trial details

NCT IDNCT00608764

SponsorBrigham and Women's Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-08

View on ClinicalTrials.gov More Pulmonary Disease, Chronic Obstructive trials

Who can participate

Age range

45 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Forced expiratory volume in 1 second (FEV1)

Timeframe: Measured at baseline

Emphysema, as shown on chest CT scan

Timeframe: Measured at baseline

Airway wall thickness on chest CT scan

Timeframe: Measured at baseline

COPD status (COPD participants versus control group participants)

Timeframe: Measured at baseline