CompletedNot Applicable

Mechanisms of Acute Asthma Exacerbations Through Molecular Analysis of Airway Secretions and Tissues

United States23 participantsStarted 2008-01

Plain-language summary

The purpose of this study is to investigate mechanisms which cause acute asthma exacerbations by examining blood and airway secretions during an acute onset (sputum or tracheal aspirates). This pilot study is intended to uncover new mechanisms of asthma exacerbation and to generate hypotheses for future study. By collaborating with Genentech, we (scientists at UCSF) plan to incorporate the latest scientific findings into our work to discover and develop new treatments for asthma.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion criteria

✓. Male and female subjects aged 18 - 70 years
✓. Medical history of asthma
✓. Currently experiencing an acute exacerbation of asthma
✓. Ability to provide informed consent or have a surrogate provide consent.
✓. Ability to provide sputum.

Exclusion criteria

✕. Cigarette smoking: Subjects must be non-smokers. Non-smokers are defined as subjects who have never smoked or who have not smoked for 1 year and have a total pack-year smoking history \< 10 packs.
✕. Pregnant women.

What they're measuring

gene expression in blood and airway secretions and tissues

Timeframe: 6 - 10 weeks

Trial details

NCT IDNCT00603629

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2009-09

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