WithdrawnPhase 3

Intraoperative Versus Postoperative Thymoglobulin in Lung Transplantation

Stopped: lack of enrollment

United States0Started 2006-01

Plain-language summary

The purpose of this study is to take a population of lung transplant recipients who meet UCLA criteria for induction chemotherapy with thymoglobulin and prospectively study weather giving the first dose intraoperatively versus postoperatively makes a difference with how patients do during and after lung transplantation.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * On a voluntary basis, all patients eligible for bilateral lung transplantation between the ages of 18-65 years (inclusive) Exclusion Criteria: * Have any known allergy to horse or rabbit antithymocyte polyclonal agents * Have a preoperative platelet count less then 100,000/mm3 * Are recipients of multiple organ transplants (either simultaneous or sequential) * Are recipients of a single lung transplantation * Have a contraindication to rabbit antithymocyte globulin based on judgement of the investigators (i.e. bleeding diathesis or overwhelming risk of intense immunosuppression) including the following patients: greater than 65 years of age, prior diagnosis of malignancy (with the exception skin malignancies), underlying suppurative lung disease (i.e. bronchiectasis, cystic fibrosis, etc.).

What they're measuring

Primary Graft Dysfunction

Timeframe: paO2/FiO2 ratio at post transplant, 24 hr, 48 hr, and 72 hr time points

Trial details

NCT IDNCT00592306

SponsorUniversity of California, Los Angeles

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2009-09

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