Capsaicin Cough Threshold in Chronic Cough Due to Postnasal Drip (NCT00588627) | Clinical Trial Compass
CompletedNot Applicable
Capsaicin Cough Threshold in Chronic Cough Due to Postnasal Drip
United States25 participantsStarted 2006-03
Plain-language summary
This study is being done to find out why some people with mucus dripping down the back of their throat have a nagging cough while others do not cough.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Postnasal drip by rhinoscopy
. Cough by visual analog scale.
. Patients have to be 18 years old or older.
. Cough-variant asthma must be excluded by a negative methacholine challenge test within one year, or documented failure of chronic cough to resolve after administration of inhaled corticosteroid (\> one-month duration). Asthma is defined by the ATS guidelines.
. Subjects must have a negative chest radiogram or Chest CT scan within 6 months.
. No active GERD symptoms (\< 7 RSI score) \& a stable dose of Proton Pump Inhibitor (4 weeks).
. Postnasal drip by rhinoscopy
. No cough by visual analog scale.
Exclusion criteria
. Presence of nasal polyposis and/or sinusitis or active GERD symptoms on examination.
. Current smokers (smoking within the 2 months prior to the study) will be excluded.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
We hypothesize that capsaicin cough sensitivity is increased in patients with PND-CC compared to subjects with PND without cough and that cough sensitivity to capsaicin will decrease with treatment for postnasal drip.
. Patients on leukotriene receptor antagonist and/ or nasal topical corticosteroids or inhaled corticosteroids. Patient must be off nasal or inhaled corticosteroid by at least 4 weeks.
. A chest radiogram is not necessary in this group.
. Patients taking leukotriene inhibitors, or using nasal steroid therapy.