CompletedNot Applicable

Capsaicin Cough Threshold in Chronic Cough Due to Postnasal Drip

United States25 participantsStarted 2006-03

Plain-language summary

This study is being done to find out why some people with mucus dripping down the back of their throat have a nagging cough while others do not cough.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Postnasal drip by rhinoscopy
✓. Cough by visual analog scale.
✓. Patients have to be 18 years old or older.
✓. Cough-variant asthma must be excluded by a negative methacholine challenge test within one year, or documented failure of chronic cough to resolve after administration of inhaled corticosteroid (\> one-month duration). Asthma is defined by the ATS guidelines.
✓. Subjects must have a negative chest radiogram or Chest CT scan within 6 months.
✓. No active GERD symptoms (\< 7 RSI score) \& a stable dose of Proton Pump Inhibitor (4 weeks).
✓. Postnasal drip by rhinoscopy
✓. No cough by visual analog scale.

Exclusion criteria

✕. Presence of nasal polyposis and/or sinusitis or active GERD symptoms on examination.
✕. Current smokers (smoking within the 2 months prior to the study) will be excluded.
✕. Patients with an upper respiratory tract infection within the preceding 8 weeks.
✕. Patients taking angiotensin converting enzyme inhibitors.
✕. Patients on leukotriene receptor antagonist and/ or nasal topical corticosteroids or inhaled corticosteroids. Patient must be off nasal or inhaled corticosteroid by at least 4 weeks.
✕. A chest radiogram is not necessary in this group.
✕. Patients taking leukotriene inhibitors, or using nasal steroid therapy.

What they're measuring

We hypothesize that capsaicin cough sensitivity is increased in patients with PND-CC compared to subjects with PND without cough and that cough sensitivity to capsaicin will decrease with treatment for postnasal drip.

Timeframe: Endpoint

Trial details

NCT IDNCT00588627

SponsorMayo Clinic

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2008-12

View on ClinicalTrials.gov More Post Nasal Drip trials