CompletedPhase 1

Enteric Oxalate Absorption Study in Unclassified Hyperoxaluria

United States114 participantsStarted 1998-12

Plain-language summary

The purpose of this study is to learn more about a condition called 'unclassified hyperoxaluria'. People with this condition have large amounts of oxalate in their urine, which can cause kidney stones and kidney failure. We do not know what causes the high level of oxalate in the urine. In this study, we will evaluate absorption of a test dose of oxalate taken orally by measuring the amount of the test dose that is eliminated in the urine. We will compare the results of affected patients to healthy volunteers.

Who can participate

Age range4 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age equal to or greater than 4 years (patient must be able to void on request). * Have good health. Exclusion Criteria: * Any prior history of renal disease, or hypertension * ALL subjects (controls and affected patients) will be asked to discontinue any diuretics, calcium supplements, H2 blockers, proton pump inhibitors or gastrointestinal motility agents for approximately one week prior to initiation of the study. * Subjects with GFR \< 50 cc/min will be excluded.

What they're measuring

Urine oxalate measured following absorption of oral oxalate dose

Timeframe: 2 years

Trial details

NCT IDNCT00588120

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-01

View on ClinicalTrials.gov More Enteric Hyperoxaluria trials