Active — Not RecruitingNot Applicable

Acute Salt Handling in Orthostatic Intolerance

United States30 participantsStarted 2007-02

Plain-language summary

The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control subjects.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosed with orthostatic intolerance by Vanderbilt Autonomic Dysfunction Center (or healthy control subject) Exclusion Criteria: * Overt or acute cause for orthostatic tachycardia * Hypertension (BP\>145/95 or need for anti-hypertensive medications) * QRS duration \> 120 msec on EKG * Pregnancy

What they're measuring

Urinary Na excretion

Timeframe: 24h and then hourly post saline load

Trial details

NCT IDNCT00581633

SponsorVanderbilt University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-12

View on ClinicalTrials.gov More Postural Tachycardia Syndrome trials