Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients

Inclusion Criteria: * Patients with a histologic diagnosis of cancer of the colon, breast, bladder, kidney, testicles, lungs, prostate, head and neck, or lymphoid organs, who have donated a diagnostic blood sample as either an inpatient or outpatient at MSKCC. * All patients who have two or more histologic diagnoses of the same primary tumor type involving the above sites. * Patients of Ashkenazi Jewish ancestry with a histologic diagnosis of cancer of any type. * Samples ascertained as part of protocol 98-024A(1) are also eligible for ascertainment in this study. Exclusion Criteria: * MSKCC patients without a histologic diagnosis of cancer of the breast, bladder, kidney, colon, testicles, lungs, prostate, or lymphoid malignancy (including all types of lymphoma) will not be eligible for the AMDeC sponsored component of the study.