Parathyroid and Thymus Transplantation in DiGeorge #931

Transplant Inclusion: * Complete DiGeorge syndrome (typical or atypical) - may have DiGeorge as part of 22q11 hemizygosity, CHARGE association, or diabetic embryopathy or they may have no associated syndromes. * Must have 1 of following: * Circulating CD3+ T cells \< 50/mm3; or * Circulating CD3+ T cells that also positive for CD45RA and CD62L must be \<50/mm3 or must be \< 5% of total T cells. * Must be \<24 months old * Laboratory studies must be done w/in 1 month of treatment: * Thyroid studies - if abnormal must be on therapy, if recommended by endocrinology: * PT and PTT must be \<2x upper limits of normal (ULN) * Absolute neutrophil count must be \>500/mm3 * Platelet count must be \>50,000/mm3 * AST and ALT must be \<5x ULN * Creatinine must be \<1.5 mg/dl * Parents must agree to have infant stay in Durham until thymus biopsy is done 2-3 months post-treatment. * Typical subjects must not have a rash with T cells on biopsy nor lymphadenopathy. * Atypical subjects have rash with T cells on biopsy; may have lymphadenopathy. * PHA proliferative responses must be tested 2x • Atypical: PHA response must be \<75,000cpm on 2 tests; test can be done while on immunosuppression. Additional Criteria for Parathyroid Treatment Inclusion * Hypoparathyroidism * At least 1 parent must agree to be parathyroid donor * Must require calcium supplementation to maintain ionized calcium \>1.0 mmol/L. Alternatively, intact PTH must be \<lower limit of normal when ionized ca…