A Randomized Clinical Trial to Prevent Recurrent CA-MRSA Infection

Inclusion Criteria: * Is a member of Kaiser Permanente Southern California (KPSC) * Have at least 1 culture positive for MRSA in the prior 12 months and at least one skin infection in the prior 12 months. The culture(s) and/or skin infection(s) will: A. Be associated with mutually exclusive patient encounters that are separated by at least 21 days. The encounters include: outpatient visits to primary care provider; outpatient visits to emergency departments or urgent care facilities; inpatient hospitalizations (admission date is considered the encounter date) AND Each patient encounter defined in section A is associated with EITHER: B. EITHER receipt of a prescription (or course) of antibiotics for a clinical infection. OR C. A visit to an outpatient setting (including primary care provider visits, emergency department visits, phone consultations, and urgent care visits) for a skin or skin structure infection. * Age is 1 month or older * Ability and willingness to take intranasal medications, topical body washes, and environmental decontamination measures. * Ability and willingness of subject or legal guardian/representative to give written informed consent. * Ability and willingness to participate in the study according to treatment allocation even if not randomized to an active intervention. Exclusion Criteria: * Current residence in a KPSC-associated chronic care facility or other chronic-care facility (e.g., a rehabilitation facility or nursing home) * Receipt o…