CompletedPhase 4

Second-Line Treatments for Anovulatory Infertility in PCOS Patients

Italy50 participantsStarted 2003-02

Plain-language summary

To date, it is still unclear the potential role of laparoscopic ovarian diathermy (LOD) in the management of polycystic ovary syndrome (PCOS)-related anovulatory infertility. Metformin administration, alone or combined with clomiphene citrate (CC), has shown to be an effective and attractive second-line treatment for ovulation induction in women with polycystic ovary syndrome (PCOS) after failure of CC treatment. The aim of the present study will be to compare in a randomized controlled fashion the efficacy of LOD with metformin plus CC administration in the treatment of the CC-resistant PCOS patients.

Who can participate

Age range18 Years – 35 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * PCOS * Clomiphene citrate-resistance * Anovulation * Infertility Exclusion Criteria: * Age \< 18 or \> 35 years * Body mass index \>35 * Neoplastic, metabolic, endocrine, hepatic, renal, and cardiovascular disorders or other concurrent medical illnesses * Current or previous use of oral contraceptives, glucocorticoids, antiandrogens, ovulation induction agents, antidiabetic and anti-obesity drugs or other drugs affecting hormone levels, carbohydrate metabolism, or appetite * Pelvic diseases * Previous pelvic surgery * Suspected peritoneal factor infertility/subfertility * Tubal or male factor infertility or sub-fertility

What they're measuring

Live-birth rate

Timeframe: fifteen months

Trial details

NCT IDNCT00558077

SponsorUniversity Magna Graecia

Sponsor typeOTHER

Study typeINTERVENTIONAL

View on ClinicalTrials.gov More Polycystic Ovary Syndrome trials