Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer

Inclusion Criteria: * Presence of a corneal ulcer at presentation * Evidence of filamentous fungus on KOH (or Giemsa or any other stain) or culture * The patient must be able to verbalize a basic understanding of the study after it is explained to the patient, as determined by physician examiner. This understanding must include a commitment to return for follow-up visits. * Willingness to be treated as an in-patient or to be treated as an out-patient and come back every 48-72 hours to receive fresh medication for 3 weeks * Appropriate consent Exclusion Criteria: * Overlying epithelial defect \< 0.5 mm at its greatest width at presentation * Impending perforation * Evidence of bacteria on Gram stain at the time of enrollment * Evidence of acanthamoeba by stain * Evidence of herpetic keratitis by history or exam * Corneal scar not easily distinguishable from current ulcer * Age less than 16 years (before 16th birthday) * Bilateral ulcers * Previous penetrating keratoplasty in the affected eye * Pregnancy (by history or urine test) or breast-feeding (by history) * Acuity worse than 6/60 (20/200) in the fellow eye (note that any acuity, uncorrected, corrected, pinhole, or BSCVA 6/60 or better qualifies for enrollment) * Known allergy to study medications (antifungal or preservative) * No light perception in the affected eye * Not willing to participate