UnknownPhase 2

Comparison of High Dose and Low Dose Dexamethasone in Preventing Post-Extubation Airway Obstruction in Adults

Taiwan80 participantsStarted 2007-04

Plain-language summary

The specific objectives were to determine whether high dose dexamethasone are more effective than low dose dexamethasone in the reduction or prevention of post-extubation airway obstruction among patients with a cuff leak volume (CLV) \< 110 mL.

Who can participate

Age range18 Years – 95 Years

SexALL

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Inclusion criteria

✓. Temperature ≤ 38°C for \> 8 hours,
✓. Discontinuous use of sedatives,
✓. Heart rate ≥ 70 and ≤ 130 /min,
✓. Systolic blood pressure (SBP) ≥ 80 mm Hg in the absence of vasopressors,
✓. Fraction of inspired oxygen (FiO2) ≤ 0.6, PaO2 ≥ 60, and partial pressure of oxygen (PaO2)/FiO2 ratio \> 200,
✓. Positive end-expiratory pressure (PEEP) ≤ 5 cm H2O,
✓. Rapid and shallow ratio of frequency to tidal volume (f/VT ≤ 105),
✓. Minute ventilation ≤ 15 L/min, and

Exclusion criteria

✕. A history of extubation during the same hospitalization
✕. Administration of corticosteroids seven days prior to extubation.

What they're measuring

absolute cuff leak volumes and relative cuff leak volume to tidal volume(%)(measured CLV-baseline CLV) X 100/ tidal volume)

Timeframe: 48 hours

Trial details

NCT IDNCT00548483

SponsorMackay Memorial Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2008-03

Contact for this trial

Chao-Hsien Lee, MD

+886-2-23926589 L49428@ms2.mmh.org.tw

View on ClinicalTrials.gov More Airway Obstruction trials