Proleukin and Rapamune in Type 1 Diabetes

Inclusion Criteria: * Diagnosed with type 1 diabetes (per ADA criteria) more than 3 but less than 48 months prior to enrollment; * 18 to 45 years of age;and * Positive for at least one islet cell autoantibody (GAD65-antibody, CA512-antibody and/or ICA). Exclusion Criteria: * Chronic use of glucocorticoids or other immunosuppressive ages 4 weeks before enrollment; * History of recurrent infections, other autoimmune diseases, cardiac disease, cataracts or other chronic medical conditions that investigators believe could compromise participant safety; * Females who are pregnant, lactating intend to get pregnant, or are unwilling to undergo pregnancy testing during the study; * Males who intend to father a pregnancy during the first 6 months of the study; or * Participation in another clinical study within the last 30 days.