RTA 744 Injection in Patients With Leptomeningeal Disease

Exclusion criteria

• . Concurrent intrathecal or intraventricular therapy for leptomeningeal disease or other malignancy.
• . Concurrent oral or intravenous cytotoxic therapy for leptomeningeal disease or other malignancy. Patients who are receiving non-cytotoxic concurrent drug for their malignancy may be allowed on the study, provided that the non-cytotoxic drug was started for at least 4 weeks prior to entry into the study and that no apparent toxicity from the non-cytotoxic drug is evident.
• . Clinical evidence of obstructive hydrocephalus or compartmentalization of CSF flow.
• . Patient has previously received anthracycline therapy up to the following cumulative doses: doxorubicin \>/= 550 mg/m\^2 (\>/= 450 mg/m\^2 if patient has had prior chest radiotherapy), epirubicin \>/= 1000 mg/m\^2 (\>/= 800 mg/m\^2 if prior chest radiation), idarubicin \>/= 150 mg/m\^2 (\>/= 130 mg/m\^2 if prior chest radiotherapy) and daunorubicin \>/= 550 mg/m\^2 (\>/= 400 mg/m\^2 if prior chest radiotherapy).
• . Patients on anticonvulsant medications or other types of medications which are known liver-enzyme inducers.
• . Patients who are pregnant or breast feeding, or adults (male or female) of reproductive potential not employing an effective method of birth control (such as oral, implantable, or injectable contraceptives ) (Women of childbearing potential must have a negative serum pregnancy test within 72 hours prior to administration of RTA 744 Injection)
• . Total urinary protein in 24 hours urine collection \> 500 mg
• . Any of the following concurrent severe and/or uncontrolled medical conditions which could compromise participation in the study: 1) Uncontrolled diabetes (patients diagnosed with Type 1 or Type 2 diabetes who are currently under treatment by a physician for this condition and are not able to control blood sugars with management for glucose levels above 250 mg/dL). 2) Active or uncontrolled infection. 3) Acute or chronic liver disease (i.e., hepatitis, cirrhosis). 4) Confirmed diagnosis of HIV infection