CompletedPhase 1/2

The Discriminative Effects of Tramadol in Humans

United States20 participantsStarted 2007-11

Plain-language summary

This research is part of a set of studies whose purpose is to test whether tramadol can be used for the treatment of opioid addiction. Tramadol is already available in the United States as a pain medicine marketed as Ultram. It has effects similar to morphine, and it may also have effects similar to other drugs like stimulants. The doses of tramadol used in this study are higher than those generally used for the treatment of pain. To be in this study a participant must be a user of opioids (drugs like heroin) and stimulants (drugs like cocaine), but cannot be addicted to either. The person must be between 21-55 years old, and generally healthy. Up to 12 people will take part in this study.

Who can participate

Age range21 Months – 55 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Study subjects are male and female non-dependent opioid users with active stimulant use. * Between the ages of 21-55 * In good physical health * Without significant psychiatric illness besides their drug use. * Females are required to provide a negative pregnancy test prior to study participation. Exclusion Criteria: * Subjects are excluded if they have evidence of significant medical (e.g., insulin dependent diabetes mellitus) or psychiatric (e.g., schizophrenia) illness. * Subjects with a history of seizures will be excluded. * Persons with current history of significant alcohol or sedative/hypnotic drug use will be excluded from study participation. * Applicants seeking treatment for their substance abuse will not be admitted to the study, and will be provided information about treatment services available.

What they're measuring

Acquisition of Discrimination Assessed by Accuracy of the Discrimination Test

Timeframe: 1 day

Discrimination Effects Assessed by Operant Responses

Timeframe: 1 day

Discrimination Effects Assessed by Point Distribution

Timeframe: 1day

Discrimination Effects Assessed by Discrete Choice

Timeframe: 1 day

Trial details

NCT IDNCT00499746

SponsorNational Institute on Drug Abuse (NIDA)

Sponsor typeNIH

Study typeINTERVENTIONAL

Primary completion2010-04

Results submitted2012-08-18

View on ClinicalTrials.gov More Opioid Abuse trials

Plain-language summary

Who can participate

Age range21 Months – 55 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.