Active — Not RecruitingPhase 2

Proton Beam Therapy for Chondrosarcoma

United States15 participantsStarted 2006-04-28

Plain-language summary

The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chondrosarcoma. The safety of this treatment will also be studied.

Who can participate

SexALL

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Inclusion criteria

✓. Pathologically confirmed Grade 1-3 chondrosarcoma of the skull base
✓. Contrast enhanced postop MRI or CT if there is clinical contraindication for MRI of the skull base obtained with 90 days of study registration at M. D. Anderson
✓. The patient has been assessed by MDACC skull base surgeons to have undergone maximal surgical debulking of disease
✓. Karnofsky Performance status greater than or equal to 60
✓. Signed informed consent

Exclusion criteria

✕. Previous irradiation of the skull base
✕. Documented evidence of disseminated metastatic disease

What they're measuring

Time to Local Recurrence

Timeframe: Baseline to local recurrence (evaluation every six months during estimated 5 year study)

Trial details

NCT IDNCT00496522

SponsorM.D. Anderson Cancer Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-08-19

View on ClinicalTrials.gov More Chondrosarcoma trials