Active — Not RecruitingPhase 2

Proton Beam Therapy for Chordoma Patients

United States19 participantsStarted 2006-09-18

Plain-language summary

The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chordoma. The safety of this treatment will also be studied.

Who can participate

SexALL

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Inclusion criteria

✓. Pathologically confirmed chordoma of the skull base
✓. Contrast enhanced postoperative MRI (CT in case MRI is contraindicated) of the skull base obtained within 90 days of study registration
✓. MDACC surgeons have determined that optimal debulking of disease has been performed.
✓. Karnofsky Performance status greater than or equal to 60
✓. Signed informed consent

Exclusion criteria

✕. Previous irradiation of the skull base
✕. Documented evidence of disseminated metastatic disease
✕. Any concurrent malignancy (other than non-melanoma skin cancers) in the last 3 years

What they're measuring

Time to Local Recurrence

Timeframe: 1 year after radiation treatments

Trial details

NCT IDNCT00496119

SponsorM.D. Anderson Cancer Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-31

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