CompletedPhase 3

Glutamate for Metabolic Intervention in Coronary Surgery

Sweden865 participantsStarted 2005-10

Plain-language summary

The main purpose of this study is to determine whether intravenous glutamate infusion given in association with surgery for unstable coronary artery disease can protect the heart from myocardial injury, postoperative heart failure and death.

Who can participate

Age range85 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * surgery for unstable coronary artery disease (unstable angina, non-STEMI) * accepted for surgery \< 2 weeks after STEMI * coronary surgery for indications above performed with or without cardiopulmonary bypass * coronary surgery for indications above with or without simultaneous valve procedure Exclusion Criteria: * informed consent not possible because of critical condition or other reason * preoperative use of inotropes or mechanical circulatory assist * preoperative dialysis * redo-procedure * unexpected intraoperative finding / event that increased the dignity of the procedure to overshadow the originally planned operation * body weight \> 125 kg * food allergy known to have caused flush, rash or asthma

What they're measuring

Number of Participants With Perioperative Myocardial Infarction, Postoperative Heart Failure or Postoperative Mortality

Timeframe: 30 days

Trial details

NCT IDNCT00489827

SponsorUniversity Hospital, Linkoeping

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2009-12

Results submitted2017-10-30

View on ClinicalTrials.gov More Coronary Artery Bypass trials