TerminatedNot Applicable

Characteristics of Dendritic Cells Before and After Gastric Banding

Stopped: Terminated due to a lack of recruitment and decision by the PI not to continue.

United States7 participantsStarted 2007-06

Plain-language summary

A research study to find out more about a specific white blood cell called a dendritic cell. These cells are found in a layer of fat in the body called the omentum. The omentum is a layer of fat that covers the bowels (intestines) and protects them. The purpose of this study is to allow us to compare dendritic cells in normal weight individuals to the dendritic cells of people who are extremely overweight. These cells will be collected from the omentum, the layer of fat that covers and protects the bowels (intestines), from the mesentery, which is another layer of fat that surrounds the intestines directly, and from the subcutaneous tissue, which is the layer of fat just under the skin.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * For gastric banding subjects to qualify for study inclusion, subjects have to have a BMI ranging from 33-40. Currently a BMI of 33 is our lower level of acceptable for bypass. Subjects with a BMI\>40 will be excluded because their fat cells are very large and therefore fragile and unsuitable for research use. Control Group: * All adult subjects 18 years or greater being seen in the minimally invasive surgery clinic for elective laparoscopic surgery will also be screened. * These will be subjects who are non-obese (BMI\<30) and undergoing laparoscopic surgery for a different indication such as hernia repair or cholecystectomy. These will be patients who are undergoing elective procedures to minimize the impact an acute inflamed abdomen may have on the fat cells. Exclusion Criteria: * Women who are pregnant or planning to become pregnant will be excluded from this study. Gastric banding cannot not be performed on pregnant women.

What they're measuring

Measure changes in dendritic cells at baseline, 6 months and 1 year following weight loss

Timeframe: 1 year

Trial details

NCT IDNCT00488930

SponsorUniversity of California, San Diego

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2011-01