Study Of Pharmacokinetics and Pharmacodynamics Effects Of GSK256073A On Healthy Volunteers

Inclusion criteria: * Healthy Adult males or females between 18 and 55 years of age, inclusive. * Female subjects must be of non-childbearing potential * Body weight \> 50 kg (110 pounds) and body mass index (BMI) 19 and 31 where: * Subjects with QTc \< 450 msec at screening (or QTc \< 480 msec for subjects with Bundle Branch Block). * A signed and dated written informed consent prior to admission to the study. * The subject is able to understand and comply with protocol requirements, instructions and protocol-stated restriction Exclusion criteria: * Systolic blood pressure \< 100 mmHg or 150 mmHg and/or diastolic blood pressure = 100 mmHg at screening. * History of significant cardiac arrhythmias * Active peptic ulcer disease (PUD) and/or history of PUD within 1 year. * A serum uric acid concentration 8mg/dL * Screening test positive for H. Pylori using the non-radioactive breath test * History of gout and/or hyperuricemia * History of Gilbert's syndrome * A serum creatinine concentration above the normal reference range * History of kidney stones * PT and/or aPTT above the reference range * History of recurrent indigestion, stomach upset or diarrhea * Liver function tests (LFTs) or creatinine phosphokinase (CPK) 1.5X ULN * Screening stool test positive for occult blood * Screening peripheral blood smear with abnormal RBCs * CBC, MCV, and/or reticulocyte count corrected for haemoglobin level above the reference range at screening * Reduced G6PD activity * Serum haptoglobi…