Growth Response in Short Children Suffering From a Disease With Growth Retardation and Treated With Somatropin

Inclusion Criteria: * Severe growth retardation (\< -2,5 height SDS and annual growth velocity (HV SDS) \< 0 SD according to Reinken (1992) and parental adjusted target height \< -1 SD according to Tanner (1986) * Chronological age \> 4 and \< 10 years, prepubertal children; for girls: Tanner breast stage B = 1, for boys: testis volume ≤ 3 ml * Any disease which is NOT part of the registered indications for GH treatment in Germany * Written informed consent from both parents and from the patients if she/he is able to receive and understand the information * GH treatment requested by an expert in pediatric endocrinology Exclusion Criteria: * Participation in any other clinical study * Unable to follow the and/or comprehend the protocol ( e.g. severe mental retardation) * Previous history of intolerance or hypersensitivity to the study drug * History of malignancy * Chromosomal anomalies with increased risk for malignancy