Effects of GH on Body Proportions and Final Height in X-Linked Hypophosphatemic Rickets (NCT00473187) | Clinical Trial Compass
UnknownPhase 1
Effects of GH on Body Proportions and Final Height in X-Linked Hypophosphatemic Rickets
GermanyStarted 2004-08
Plain-language summary
X-linked hypophosphatemic rickets (XLH) is characterized by rickets, disproportionate short stature, impaired renal phosphate reabsorption and vitamin D metabolism. Despite oral phosphate and vitamin D treatment, most children with XLH demonstrate reduced adult height. The main objective of the study is to determine the beneficial effects of recombinant human growth hormone (rhGH) therapy on body proportions after 36 month in these patients. Secondary objective is to monitor side effects of the therapy.
Who can participate
Age range
3 Years – 10 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Tanner stages of puberty B1, G1
* body height \< 2,5 SDS
* growth velocity \< 75%
* confirmed diagnosis of XLHR
* conservative treatment for at least 1 year (phosphate, vitamin D)
* informed consent, written agreement
Exclusion Criteria:
* growth hormone deficiency
* hypothyreosis
* severe rickets
* severe physical deformities
* severe hyperparathyreoidism
* chronic renal failure
* complex syndrome involving failure to thrive
* chronic disease with failure to thrive
* impairment of glucose tolerance
* Tanner stages of puberty greater than B1, G1
* medical history of malignancy
* therapy with growth hormone, glucocorticoides, anabolica
* attending another clinical trial
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.