CompletedNot Applicable

Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men

United States40 participantsStarted 2002-10

Plain-language summary

Type 2 diabetes is one of the most common metabolic disorders in the U.S, estimated to affect 16 million Americans. Established risk factors for this disease include obesity, increased waist/hip ratio, high insulin levels in the blood, and insulin resistance. Testosterone may play a role in developing or preventing diabetes, but we do not yet know for sure. The purpose of this research study is to determine if changing testosterone levels in men will result in changes in insulin sensitivity. Information learned form this research study may have important public health implications and may point to new strategies for treating or preventing diabetes.

Who can participate

Age range18 Years – 75 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Healthy men: Good general health, * Normotensive, * Normal testosterone levels, * No medications known to influence glucose homeostasis or testosterone levels IHH men: * Good general health; * Normal thyroid, adrenal, and GH axes; * Normal prolactin levels; * No abnormalities on imaging of the hypothalamic-pituitary region; * No medications known to influence glucose homeostasis; * Must have been off hormone therapy for a suitable washout period depending on the type of prior androgen replacement

What they're measuring

insulin sensitivity

Timeframe: 2 timepoints: with a normal serum testsoterone and in a castrate state of low serum testoserone

Trial details

NCT IDNCT00470990

SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sponsor typeNIH

Study typeINTERVENTIONAL

Primary completion2008-06

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