Pilot Study of High Dose Liposomal Amphotericin B Efficacy in Initial Zygomycosis Treatment

Inclusion Criteria: * Presence on a tissue biopsy of large non septated hyphae compatible with zygomycete * Presence of a zygomycete in culture associated with clinical or radiological abnormalities compatible with fungal invasive infection. Exclusion Criteria: * Life expectancy below 72 hours, * Pregnancy, breast feeding, * Polyene hypersensitivity, * Absence of histologic or mycologic zygomycosis documentation, * Absence of informed consent, * Previous treatment with polyene or other antifungal active on zygomycete (posaconazole, itraconazole) over 5 days during the month previous inclusion