Sitagliptin Treatment in Patients With Type 2 DM After Kidney Transplant

Inclusion Criteria: * Type 2 Diabetes Mellitus * Most recent HbA1C 6.5-10% * 1 year post kidney transplant Exclusion Criteria: * Patients treated primarily with insulin for their diabetes * Kidney allograft not functional at entry or estimated creatinine clearance of \<30 ml/min * Clinical course complicated by persistent nausea * severe gastroparesis * Severe recurrent hypoglycemia (\>1 hypoglycemic episode requiring the help of another person per week). * Patients on dialysis therapy * Unstable renal function in the preceding 3 months * Serum transaminases \>2 times normal at study entry * Smokers * Pregnant or planning to become pregnant * Lactating * Recipients of multi-organ transplants * Unstable medical conditions which result in multiple hospitalizations or a severely restricted lifestyle * Hemoglobin \<10.0g/dl * Use of digoxin * Patients receiving their primary care outside of UNMC * Inability to come to follow-up visits as a part of the protocol * Patients not taking tacrolimus and sarolimus as part of their immunosuppressive therapy