CompletedNot Applicable

MRI in Evaluating Early Response to Chemotherapy in Women With Infiltrating Breast Cancer

France16 participantsStarted 2006-02

Plain-language summary

RATIONALE: Diagnostic procedures, such as magnetic resonance imaging (MRI), may help in learning how well chemotherapy works to kill breast cancer cells and allow doctors to plan better treatment. Drugs used in chemotherapy, such as epirubicin and docetaxel, may stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. PURPOSE: This clinical trial is studying MRI in evaluating early response to chemotherapy in women receiving chemotherapy for infiltrating breast cancer.

Who can participate

Age range18 Years – 70 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

DISEASE CHARACTERISTICS: * Histologically confirmed infiltrative breast cancer meeting 1 of the following criteria: * Operable T2 or T3, M0 disease * Locally advanced disease (T4a, b, or c) * No T4d disease * Indication for neoadjuvant chemotherapy before breast-conserving surgery * No desire by patient for complete mastectomy * No overexpression of HER-2 * No multifocal tumor * Hormone receptor status not specified PATIENT CHARACTERISTICS: * Female * Menopausal status not specified * Life expectancy \> 6 months * No contraindication to MRI with contrast, including any of the following: * Claustrophobia * Prior major allergies * Cardiac pacemaker * Surgical clips * Certain cardiac valves * Sunken or hollow filters * Implanted pump * Cochlear implants * Metallic foreign body (intra-ocular) * No contraindication to chemotherapy or surgery * No other serious condition that would preclude study therapy * No other uncontrolled medical condition, including any of the following: * Thyroid disease * Neuropsychiatric disease * Infection * Insufficient coronary capacity * NYHA class III-IV heart disease * No HIV positivity * Not pregnant or nursing PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No prior chemotherapy, radiotherapy, or surgery for ipsilateral breast cancer * No prior biopsy of tumor before MRI * No MRI at another center within the past 15 days * No participation in another investigational study of anticancer ther…

What they're measuring

Reproducibility of the MRI Vascular Permeability (Kep)

Timeframe: two months after start of neoadjuvant chemotherapy

Reproducibility of the MRI Vascular Permeability (HA)

Timeframe: two months after start of neoadjuvant chemotherapy

Trial details

NCT IDNCT00462696

SponsorInstitut Bergonié

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2008-12-31

Results submitted2025-08-26