CompletedNot Applicable

Evaluation of Etomidate on Adrenal Function in Trauma Patients

United States30 participantsStarted 2006-02

Plain-language summary

Trauma patients are at increased risk for adrenal function insufficiency. A commonly used agent for rapid sequence intubation (RSI) is known to decrease adrenal function. We want to determine the incidence of adrenocortical insufficiency and its significance during the first 24 hours of resuscitation following RSI in trauma patients.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Trauma mechanism of injury * Patient requires rapid sequence induction for ventilatory support Exclusion Criteria: * \<18 years old * Prisoners * Pregnant women * Patients with a history of adrenal insufficiency * Patients with adrenal trauma documented by CT scan * Patients receiving corticosteroids in the previous year

What they're measuring

Cortisol Levels Pre and Post Rapid Sequence Induction and Cortisol Stimulation Test

Timeframe: pre RSI, 4-6 hours post RSI, and again 60 mins later following ACTH stimulation test

Postintubation Cortisol (Baseline Cortisol Level)

Timeframe: postintubation (baseline cortisol level)

Change in Baseline Cortisol

Timeframe: 4-6hr after RSI

Cortisol Level 60 Minutes After Cortisol Stimulating Test (CST)

Timeframe: 60 minutes after administration of cotrosyn

Trial details

NCT IDNCT00462644

SponsorUniversity of Tennessee

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2006-08

Results submitted2009-03-04

View on ClinicalTrials.gov More Adrenal Insufficiency trials