CompletedNot Applicable

Evaluation of Etomidate on Adrenal Function in Trauma Patients

United States30 participantsStarted 2006-02

Plain-language summary

Trauma patients are at increased risk for adrenal function insufficiency. A commonly used agent for rapid sequence intubation (RSI) is known to decrease adrenal function. We want to determine the incidence of adrenocortical insufficiency and its significance during the first 24 hours of resuscitation following RSI in trauma patients.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Trauma mechanism of injury * Patient requires rapid sequence induction for ventilatory support Exclusion Criteria: * \<18 years old * Prisoners * Pregnant women * Patients with a history of adrenal insufficiency * Patients with adrenal trauma documented by CT scan * Patients receiving corticosteroids in the previous year

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Cortisol Levels Pre and Post Rapid Sequence Induction and Cortisol Stimulation Test

Timeframe: pre RSI, 4-6 hours post RSI, and again 60 mins later following ACTH stimulation test

Postintubation Cortisol (Baseline Cortisol Level)

Timeframe: postintubation (baseline cortisol level)

Change in Baseline Cortisol

Timeframe: 4-6hr after RSI

Cortisol Level 60 Minutes After Cortisol Stimulating Test (CST)

Timeframe: 60 minutes after administration of cotrosyn

Trial details

NCT IDNCT00462644

SponsorUniversity of Tennessee

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2006-08

Results submitted2009-03-04

View on ClinicalTrials.gov More Adrenal Insufficiency trials