See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Severe respiratory distress (use of respiratory accessory muscles);
* Respiratory rate \> 25 per minute;
* Respiratory acidosis (pH \< 7.35 and PaCO2 \> 45 mmHg);
* PaO2/FiO2 \< 250
Exclusion Criteria:
* Age \< 18 years;
* Facial deformities;
* Pneumothorax;
* Shock or systolic arterial pressure below 90 mmHg with amine infusion;
* Life-threatening arrhythmias;
* Need for immediate endotracheal intubation (PaO2/FiO2 \< 100 with FiO2 100%, respiratory rate \< 10, GCS \< 8);
* Lack of co-operation from the patient;
* Recent esophageal-gastric surgery;
* Inability to clear secretions;
* Drugs that may interfere with BNP secretion;
* Severe obesity;
* Hepatic cirrhosis with ascitis;
* Endocrine disease.