CompletedNot Applicable

Risk Factors for Barrett's Esophagus in Patients With BE, Gastroesophageal Reflux, or Gastrointestinal Bleeding

United States170 participantsStarted 2005-08

Plain-language summary

RATIONALE: A study that evaluates DNA changes and other disease-related health information in patients with Barrett's esophagus, gastroesophageal reflux, or gastrointestinal bleeding may help doctors learn more about the risk factors for Barrett's esophagus. PURPOSE: This clinical trial is looking at DNA changes and other disease-related health information as risk factors for Barrett's esophagus in patients with Barrett's esophagus, gastroesophageal reflux, or gastrointestinal bleeding.

Who can participate

Age range18 Years – 90 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

DISEASE CHARACTERISTICS: * Undergoing elective esophagogastroduodenoscopy for any of the following reasons: * Surveillance of Barrett's esophagus * Evaluation of severe or refractory gastroesophageal reflux disease or chest pain thought to be due to reflux * Gastrointestinal bleeding PATIENT CHARACTERISTICS: * Not pregnant PRIOR CONCURRENT THERAPY: * Not specified

What they're measuring

Polymorphisms in detoxifying enzyme systems such as glutathione S-transferases (e.g., mu, theta, pi)

Timeframe: 2000-2013

Polymorphisms in other xenobiotic metabolism pathways (e.g., CYP1A1, CYP2E1, CYP3A4/5, NQO1, mEH, NAT-2)

Timeframe: 2000-2013

Polymorphisms in inflammatory gene pathways (e.g., MPO, MnSOD, IGF, IGFBF3, Il1-beta)

Timeframe: 2000-2013

Polymorphisms in DNA repair genes or the p53 pathways (e.g., ERCC2, XRCC1, p53, p73, CCND1, p21)

Timeframe: 2000-2013

Trial details

NCT IDNCT00445653

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2013-03

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