CompletedNot Applicable

Genetic Analysis Using Blood or Bone Marrow From Participants With Neuroblastoma or Noncancerous Conditions

United States9,350 participantsStarted 2006-12-11

Plain-language summary

This laboratory study is looking at genes in participants with neuroblastoma or noncancerous conditions. Identifying genes related to cancer may help in the study of cancer. It may also help doctors predict who is at risk of developing neuroblastoma.

Who can participate

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient: * Diagnosis of neuroblastoma * Banked constitutional and genomic DNA within COG-ANBL00B1 Neuroblastoma Biology protocol or another COG Biology Protocol * At least 1.0 ?g of DNA available * Control (age, race, and gender-matched): * No diagnosis of cancer * May have other conditions, including any of the following: * Asthma * Inflammatory bowel disease * Attention-deficit disorder * Obesity

What they're measuring

Neuroblastoma predisposition genes

Timeframe: Up to 4 years

Single nucleotide polymorphism (SNP) allele disease association

Timeframe: Up to 4 years

SNP haplotype disease association

Timeframe: Up to 4 years

Validation of SNP allele and haplotype disease association

Timeframe: Up to 4 years

SNP association with phenotypic subsets (i.e., high-risk vs no high-risk disease; MYCN amplification vs no MYCN amplification)

Timeframe: Up to 4 years

Trial details

NCT IDNCT00436696

SponsorChildren's Oncology Group

Sponsor typeNETWORK

Study typeOBSERVATIONAL

Primary completion2016-05-05

View on ClinicalTrials.gov More Localized Resectable Neuroblastoma trials