Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors

Inclusion Criteria: * Diagnosis: Poor Prognosis Non-Seminomas Germ Cell Tumor in ≥ PR1/CR1 or Good or Intermediate Prognosis Seminomas and Non- Seminomas Germ Cell Tumor in ≥ PR1 or ≥ CR2 as defined by the International Germ Cell Cancer Consensus Classification. Patients with increasing tumor markers only (i.e. no imaging evidence of progressive disease) are eligible for transplant. * Age: ≥ 10 years and \< 70 years of age. * Performance status: Karnofsky ≥ 80% (subjects ≥ 16 years of age) Lansky ≥ 80% for subject 10 - 15 years of age * Life expectancy: Greater than 8 weeks. * Patients must have normal organ function as defined below: * Hematologic: * Hemoglobin \> 8 gm/dL without transfusion and off erythropoietin for 14 days or Aranesp for 21 days * White blood cells (WBC) \> 2.5 x 10\^9/L with an absolute neutrophile count (ANC) \> 1.5 x 10\^9/L and off G-CSF or GM-CSF for 10 days or Neulasta for 21 days * Platelets \> 100 x 10\^9/L without transfusion and/or a bone marrow cellularity of ≥ 20% * Renal: Creatinine ≤ 2.0 mg/dl or creatinine clearance \> 50 ml/min. * Hepatic: Total bilirubin ≤ 2.0 mg/dl, AST and alkaline phosphatase \< 5 x upper limit of normal. No history of severe prior or ongoing chronic liver disease. * Cardiac: Patients must be free of symptoms of uncontrolled cardiac disease including unstable angina, decompensated congestive heart failure, or arrhythmia. LVEF ≥45% by MUGA/ECHO. * Pulmonary: Patients must have no significant obs…